Aspirin for unstable angina?

نویسنده

  • M C Petch
چکیده

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Platelet function testing in cardiovascular diseases.

Case presentation 1: Mr F. is a 60-year-old man with unstable angina who takes aspirin, 81 mg/day. A platelet function test demonstrates that his platelets are “resistant” to aspirin. Should his treatment be changed? Case presentation 2: Mr K. is a 60year-old man with unstable angina who takes aspirin, 81 mg/day, and clopidogrel, 75 mg/day. A platelet function test demonstrates that his platele...

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Antiplatelet treatment in unstable angina: aspirin, clopidogrel, glycoprotein IIb/IIIa antagonist, or all three?

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Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis.

OBJECTIVE To estimate the risk of myocardial infarction (MI) and death in patients with unstable angina who are treated with aspirin plus heparin compared with patients treated with aspirin alone. DATA SOURCES Studies were retrieved using MEDLINE, bibliographies, and consultation with experts. STUDY SELECTION Only published trials that enrolled patients with unstable angina, randomized part...

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Combination Antithrombotic Therapy in Unstable Rest Angina and Non-Q-Wave Infarction in Nonprior Aspirin Users

Background The purpose of this study was to compare combination antithrombotic therapy with aspirin plus anticoagulation versus aspirin alone, when added to conventional antianginal therapy in patients with unstable rest angina or non-Q-wave myocardial infarction who were nonprior aspirin users. Methods and Results Two hundred fourteen patients were randomized; 109 were randomized to receive as...

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Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina.

BACKGROUND Unstable angina is associated with enhanced lipid peroxidation and reduced antioxidant defenses. We have previously reported aspirin failure in the suppression of enhanced thromboxane (TX) biosynthesis in a subset of episodes of platelet activation in this setting. We tested the hypothesis that the in vivo formation of the F(2)-isoprostane 8-iso-prostaglandin (PG)F(2alpha), a bioacti...

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عنوان ژورنال:
  • British medical journal

دوره 293 6538  شماره 

صفحات  -

تاریخ انتشار 1986